SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a

被引：54

作者：

Kim, Min-Ju ^{[4
,7
]}

Ahn, Kyungsook ^{[7
]}

Park, Seong-Hoon ^{[1
]}

Kang, Hong-Jun ^{[1
]}

Jang, Bong Geom ^{[7
]}

Oh, Soo-Jin ^{[1
]}

Oh, Sun-Mee ^{[1
]}

Jeong, Yu-Jin ^{[1
]}

Heo, Jee-In ^{[1
,5
]}

Suh, Jun-Gyo ^{[2
,5
]}

Lim, Soon Sung ^{[5
,6
]}

Ko, Yoon-Jung ^{[5
]}

Huh, Sung-Oh ^{[3
,5
]}

Kim, Sung Chan ^{[1
]}

Park, Jae-Bong ^{[1
]}

Kim, Jaebong ^{[1
]}

Kim, Jong-Il ^{[8
]}

Jo, Sangmee Ahn ^{[7
]}

Lee, Jae-Yong ^{[1
,5
]}

机构：

[1] Hallym Univ, Coll Med, Dept Biochem, Chunchon 200702, Gangwon Do, South Korea

[2] Hallym Univ, Coll Med, Dept Med Genet, Chunchon 200702, Gangwon Do, South Korea

[3] Hallym Univ, Coll Med, Dept Pharmacol, Chunchon 200702, Gangwon Do, South Korea

[4] Hallym Univ, Coll Med, Dept Anat & Neurobiol, Chunchon 200702, Gangwon Do, South Korea

[5] Hallym Univ, Coll Med, Inst Nat Med, Chunchon 200702, Gangwon Do, South Korea

[6] Hallym Univ, Dept Food Sci & Nutr, Chunchon 200702, Gangwon Do, South Korea

[7] Natl Inst Hlth, Ctr Biomed Sci, Div Brain Dis, Seoul 122701, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Biochem, Seoul 100799, South Korea

来源：

FEBS LETTERS | 2009年 / 583卷 / 07期

关键词：

SIRT1; FOXO3a; Nicotinamide; Neuronal differentiation; Neuroblastoma; FORKHEAD TRANSCRIPTION FACTOR; HISTONE DEACETYLASE; NEURONAL DIFFERENTIATION; GROWTH-FACTOR; SUPPRESSION; INHIBITION; ACTIVATION; SH-SY5Y; INSULIN; DISEASE;

D O I：

10.1016/j.febslet.2009.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To examine the function of SIRT1 in neuronal differentiation, we employed all-trans retinoic acid (ATRA)-induced differentiation of neuroblastoma cells. Nicotinamide inhibited neurite outgrowth and tyrosine hydroxylase (TH) expression. Inhibition of PARP or histone deacetylase did not inhibit TH expression, showing the effect to be SIRT1 specific. Expression of FOXO3a and its target proteins were increased during the differentiation and reduced by nicotinamide. FOXO3a deacetylation was increased by ATRA and blocked by nicotinamide. SIRT1 and FOXO3a siRNA inhibited ATRA-induced up-regulation of TH and differentiation. Taken together, these results indicate that SIRT1 is involved in ATRA-induced differentiation of neuroblastoma cells via FOXO3a. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1183 / 1188

页数：6

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