Photo-induced processes in collagen-hypericin system revealed by fluorescence spectroscopy and multiphoton microscopy

被引：9
|
作者：
Hovhannisyan, V. [1 ]
Guo, H. W. [1 ]
Hovhannisyan, A. [2 ]
Ghukasyan, V. [3 ]
Buryakina, T. [1 ]
Chen, Y. F. [1 ]
Dong, C. Y. [1 ,4 ]
机构：
[1] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan
[2] European Reg Educ Acad, Yerevan, Armenia
[3] Univ N Carolina, Neurosci Ctr, Chapel Hill, NC USA
[4] Natl Taiwan Univ, Ctr Quantum Sci & Engn, Taipei 106, Taiwan
来源：
BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 05期
关键词：
PHOTODYNAMIC THERAPY; IN-VIVO; GENERATION; MELANOMA;
D O I：
10.1364/BOE.5.001355
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Collagen is the main structural protein and the key determinant of mechanical and functional properties of tissues and organs. Proper balance between synthesis and degradation of collagen molecules is critical for maintaining normal physiological functions. In addition, collagen influences tumor development and drug delivery, which makes it a potential cancer therapy target. Using second harmonic generation, two-photon excited fluorescence microscopy, and spectrofluorimetry, we show that the natural pigment hypericin induces photosensitized destruction of collagen-based tissues. We demonstrate that hypericin-mediated processes in collagen fibers are irreversible and may be used for the treatment of cancer and collagen-related disorders. (C) 2014 Optical Society of America
引用
收藏
页码：1355 / 1362
页数：8
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