Zebrafish models of cancer: progress and future challenges

被引：40
|
作者：
Yen, Jennifer [1 ]
White, Richard M. [2 ,3 ]
Stemple, Derek L. [1 ]
机构：
[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England
[2] Mem Sloan Kettering Canc Ctr, New York, NY 11788 USA
[3] Weill Cornell Med Coll, New York, NY 11788 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2014年 / 24卷
基金：
英国惠康基金;
关键词：
REGULATED TRANSGENIC ZEBRAFISH; ACUTE LYMPHOBLASTIC-LEUKEMIA; ZINC-FINGER NUCLEASES; T-CELL LEUKEMIA; IN-VIVO; EMBRYONAL RHABDOMYOSARCOMA; GENE-EXPRESSION; BRAF MUTATIONS; MELANOMA; TUMORIGENESIS;
D O I：
10.1016/j.gde.2013.11.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The need for scalable strategies to probe the biological consequences of candidate cancer genes has never been more pressing. The zebrafish, with its capacity for high-throughput transgenesis, in vivo imaging and chemical/genetic screening, has ideal features for undertaking this task. Unique biological insights from zebrafish have already led to the identification of novel oncogenic drivers and small molecules being used to treat the human cancer. This review summarizes the recent main findings and describes pertinent areas where the zebrafish can greatly contribute to our understanding of cancer biology and treatment.
引用
收藏
页码：38 / 45
页数：8
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