Estimation of Ibuprofen in Bulk and Tablets Using Ibuprofen Sodium as Hydrotropic Solubilizing Agent

被引：0
|
作者：
Maheshwari, R. K. [1 ]
Bishnoi, S. R. [1 ]
Kumar, D. [1 ]
Murlikrishna, N. V. [1 ]
机构：
[1] Shri GS Inst Technol & Sci, Dept Pharm, Indore 452003, Madhya Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 08期
关键词：
Ibuprofen; Ibuprofen sodium; Hydrotropy; Titrimetry; SPECTROPHOTOMETRIC ANALYSIS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present investigation, hydrotropic solubilization phenomenon has been employed to solubilize the, poorly water-soluble anti-inflammatory drug, ibuprofen by use of 0.5 M of ibuprofen sodium (an economic drug) solution to carry out titrimetric analysis (in bulk drug sample and tablets) precluding the use of organic solvents. The methods are new, simple, accurate, reproducible, inexpensive and eco-friendly. The results of analysis by proposed methods of analysis compared well with the results of standard pharmacopoeial methods. Recovery studies and statistical parameters validated the proposed methods.
引用
收藏
页码：5897 / 5900
页数：4
相关论文
共 50 条
  • [21] Estimation of ibuprofen and famotidine in tablets by second order derivative spectrophotometery method
    Shah, Dimal A.
    Suthar, Dixita J.
    Nagda, Chirag D.
    Chhalotiya, Usman K.
    Bhatt, Kashyap K.
    [J]. ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 : S105 - S108
  • [22] Forced degradation of ibuprofen in bulk drug and tablets: Determination of specificity, selectivity, and the stability-indicating nature of the USP ibuprofen assay method
    Farmer, Sherri
    Anderson, Pamela
    Burns, Philip
    Velagaleti, Ranga
    [J]. Pharmaceutical Technology North America, 2002, 26 (05): : 28 - 42
  • [23] A novel formulation of ibuprofen sodium has a safety profile comparable to standard ibuprofen tablets: a pooled analysis of randomized clinical trials
    Kellstein, D.
    Leyva, R.
    Jayawardena, S.
    [J]. JOURNAL OF PAIN, 2013, 14 (04): : S72 - S72
  • [24] A novel formulation of ibuprofen sodium has a faster onset of analgesia than standard ibuprofen tablets in the treatment of postoperative dental pain
    Kellstein, D.
    Brain, P.
    Leyva, R.
    Doyle, G.
    [J]. JOURNAL OF PAIN, 2013, 14 (04): : S72 - S72
  • [25] Ibuprofen Sodium Is Absorbed Faster than Standard Ibuprofen Tablets: Results of Two Open-Label, Randomized, Crossover Pharmacokinetic Studies
    Legg T.J.
    Laurent A.L.
    Leyva R.
    Kellstein D.
    [J]. Drugs in R&D, 2014, 14 (4) : 283 - 290
  • [26] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF IBUPROFEN IN BULK DRUG AND TABLETS
    TSAO, JC
    SAVAGE, TS
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1985, 11 (05) : 1123 - 1131
  • [27] A novel formulation of ibuprofen sodium has a faster onset of analgesia than standard ibuprofen tablets in the treatment of postoperative dental pain.
    Brain, Patrick
    Leyva, Rina
    Kellstein, David
    [J]. PHARMACOTHERAPY, 2013, 33 (10): : E225 - E225
  • [28] Quantitative Analysis of Hydrochlorothiazide Tablets Using Lignocaine Hydrochloride as Hydrotropic Agent
    Maheshwari, R. K.
    Deswal, S.
    Tiwari, D.
    Ali, N.
    Jain, S.
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (02) : 1642 - 1644
  • [29] Precipitation of Ibuprofen Sodium using compressed carbon dioxide as antisolvent
    Bakhbakhi, Yousef
    Alfadul, Sulaiman
    Ajbar, AbdelHamid
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 48 (1-2) : 30 - 39
  • [30] Enteric coating of ibuprofen tablets (200 mg) using an aqueous dispersion system
    Bushra, Rabia
    Shoaib, Muhammad Harris
    Aslam, Nousheen
    Mehmood, Zafar Alam
    Hashmat, Durriya
    [J]. BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 46 (01) : 99 - 107
12345