Estimation of ibuprofen and famotidine in tablets by second order derivative spectrophotometery method

被引:7
|
作者
Shah, Dimal A. [1 ]
Suthar, Dixita J. [1 ]
Nagda, Chirag D. [1 ]
Chhalotiya, Usman K. [1 ]
Bhatt, Kashyap K. [1 ]
机构
[1] Indukaka Ipcowala Coll Pharm, PB 53, Vitthal Udyognagar 388121, Gujarat, India
关键词
Ibuprofen (IBU); Famotidine (FAM); Second order UV spectrophotometry; Validation; CHROMATOGRAPHIC METHOD;
D O I
10.1016/j.arabjc.2012.07.013
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple and accurate method for the analysis of ibuprofen (IBU) and famotidine (FAM) in their combined dosage form was developed using second order derivative spectrophotometery. IBU and FAM were quantified using second derivative responses at 272.8 nm and 290 nm in the spectra of their solutions in methanol. The calibration curves were linear in the concentration range of 100-600 mu g/mL for IBU and 5-25 mu g/mL for FAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of IBU and FAM in their combined dosage form. (C) 2012 Production and hosting by Elsevier B. V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码:S105 / S108
页数:4
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