Estimation of Ibuprofen in Bulk and Tablets Using Ibuprofen Sodium as Hydrotropic Solubilizing Agent

被引：0
|
作者：
Maheshwari, R. K. [1 ]
Bishnoi, S. R. [1 ]
Kumar, D. [1 ]
Murlikrishna, N. V. [1 ]
机构：
[1] Shri GS Inst Technol & Sci, Dept Pharm, Indore 452003, Madhya Pradesh, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 08期
关键词：
Ibuprofen; Ibuprofen sodium; Hydrotropy; Titrimetry; SPECTROPHOTOMETRIC ANALYSIS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present investigation, hydrotropic solubilization phenomenon has been employed to solubilize the, poorly water-soluble anti-inflammatory drug, ibuprofen by use of 0.5 M of ibuprofen sodium (an economic drug) solution to carry out titrimetric analysis (in bulk drug sample and tablets) precluding the use of organic solvents. The methods are new, simple, accurate, reproducible, inexpensive and eco-friendly. The results of analysis by proposed methods of analysis compared well with the results of standard pharmacopoeial methods. Recovery studies and statistical parameters validated the proposed methods.
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页码：5897 / 5900
页数：4
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