Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp Tu 6075 -: II.: Structure elucidation

被引：0

作者：

Höltzel, A

Schmid, DG

Nicholson, GJ

Stevanovic, S

Schimana, J

Gebhardt, K

Fiedler, HP

Jung, G

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[2] Univ Tubingen, Interfak Inst Zellbiol, D-72076 Tubingen, Germany

[3] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 06期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of new lipopeptide antibiotics, arylomycins A and B, were elucidated by a combination of ESI-FTICR-mass spectrometry, NMR spectroscopy, EDMAN sequencing, and fatty acid and chiral amino acid analyses. The colourless arylomycins A share the peptide sequence Of D-N-methylseryl(2)(D-MeSer(2))-D-alanyl(3)-glycyl(4)-N-methyl-4-hydroxyphenylglycyl(5)- (MeHpg(5))-L-alanyl(6)-tyrosine7 cyclised by a [3,3]biaryl bond between MeHpg(5) and Tyr(7). The yellow arylomycins B differ from arylomycins A by nitro substitution of Tyr(7). The N-termini of arylomycins A and B are acylated with saturated C(11)similar toC(15) fatty acids (fa(1)) comprising n, iso, and anteiso isomers. Arylomycins A and B represent the first examples of biaryl-bridged lipopeptides.

引用

页码：571 / 577

页数：7

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