Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637 -: II.: Structure elucidation of erabulenols A and B

被引：16
|
作者：
Tabata, N
Tomoda, H
Omura, S [1 ]
机构：
[1] Kitasato Inst, Biol Funct Res Ctr, Minato Ku, Tokyo 108, Japan
[2] Kitasato Univ, Grad Sch Pharmaceut Sci, Tokyo 108, Japan
来源：
JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 07期
关键词：
D O I：
10.7164/antibiotics.51.624
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Structures of erabulenols A and B, novel fungal inhibitors of cholesteryl ester transfer protein were elucidated by spectroscopic studies including various NMR measurements. Erabulenols consist of a phenalenone skeleton and a 1,2,2-trimethyltetrahydrofuran moiety in common. Erabulenol B possesses an additional 2,6-dihydroxy-5-methyl-3-methylketonyl benzyl moiety. The absolute stereochemistry at the C-2' position of erabulenol A was deduced as S by comparison of the optical rotation with that of other related compounds.
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收藏
页码：624 / 628
页数：5
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