Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637 -: II.: Structure elucidation of erabulenols A and B

被引：16

作者：

Tabata, N

Tomoda, H

Omura, S ^{[1
]}

机构：

[1] Kitasato Inst, Biol Funct Res Ctr, Minato Ku, Tokyo 108, Japan

[2] Kitasato Univ, Grad Sch Pharmaceut Sci, Tokyo 108, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 07期

关键词：

D O I：

10.7164/antibiotics.51.624

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structures of erabulenols A and B, novel fungal inhibitors of cholesteryl ester transfer protein were elucidated by spectroscopic studies including various NMR measurements. Erabulenols consist of a phenalenone skeleton and a 1,2,2-trimethyltetrahydrofuran moiety in common. Erabulenol B possesses an additional 2,6-dihydroxy-5-methyl-3-methylketonyl benzyl moiety. The absolute stereochemistry at the C-2' position of erabulenol A was deduced as S by comparison of the optical rotation with that of other related compounds.

引用

页码：624 / 628

页数：5

共 35 条

[31] Tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp MK993-dF2 -: II.: Structure determination and synthesis
Momose, I
Sekizawa, R
Hirosawa, S
Ikeda, D
Naganawa, H
Iinuma, H
Takeuchi, T
JOURNAL OF ANTIBIOTICS, 2001, 54 (12): : 1004 - 1012
[32] Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation (vol 62, pg 207, 2009)
Yamazaki, Hiroyuki
Omura, Satoshi
Tomoda, Hiroshi
JOURNAL OF ANTIBIOTICS, 2009, 62 (11): : 653 - 654
[33] GLISOPRENINS, NEW INHIBITORS OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY GLIOCLADIUM-SP FO-1513 .2. STRUCTURE ELUCIDATION OF GLISOPRENIN-A AND GLISOPRENIN-B
NISHIDA, H
HUANG, XH
TOMODA, H
OMURA, S
JOURNAL OF ANTIBIOTICS, 1992, 45 (10): : 1669 - 1676
[34] ISOCHROMOPHILONE-I AND ISOCHROMOPHILONE-II, NOVEL INHIBITORS AGAINST GP120-CD4 BINDING PRODUCED BY PENICILLIUM MULTICOLOR FO-2338 .2. STRUCTURE ELUCIDATION (VOL 48, PG 708, 1995)
MATSUZAKI, K
TANAKA, H
OMURA, S
JOURNAL OF ANTIBIOTICS, 1995, 48 (11): : C2 - C2
[35] Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp NA-148 II.: Physico-chemical properties and structure elucidation
Takahashi, S
Nakano, T
Koiwa, T
Noshita, T
Funayama, S
Koshino, H
Nakagawa, A
JOURNAL OF ANTIBIOTICS, 2000, 53 (02): : 163 - 170

← 1 2 3 4 →