Halogen dance in pyrazole 1-oxides:: synthesis of pyrazolo[3,4-c]quinoline 1-oxides

被引：16
|
作者：
Eskildsen, J
Ostergaard, N
Vedso, P
Begtrup, M
机构：
[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark
[2] ACADIA Pharmaceut AS, DK-2600 Glostrup, Denmark
来源：
TETRAHEDRON | 2002年 / 58卷 / 38期
关键词：
pyrazole; 1-oxides; metalation; halogen dance; pyrazolo[3,4-c]quinolines;
D O I：
10.1016/S0040-4020(02)00858-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a new series of 3-substituted pyrazolo[3,4-c]quinoline 1-oxides is presented. Regioselective bromine-magnesium exchange of 2-benzylated 3,4,5-tribromopyrazole 1-oxides and subsequent halogen dance of the resulting monometalated intermediates was used to synthesize fused pyrazoloquinoline 1-oxides. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7635 / 7644
页数：10
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