Halogen dance in pyrazole 1-oxides:: synthesis of pyrazolo[3,4-c]quinoline 1-oxides

被引：16

作者：

Eskildsen, J

Ostergaard, N

Vedso, P

Begtrup, M

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

[2] ACADIA Pharmaceut AS, DK-2600 Glostrup, Denmark

来源：

TETRAHEDRON | 2002年 / 58卷 / 38期

关键词：

pyrazole; 1-oxides; metalation; halogen dance; pyrazolo[3,4-c]quinolines;

D O I：

10.1016/S0040-4020(02)00858-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new series of 3-substituted pyrazolo[3,4-c]quinoline 1-oxides is presented. Regioselective bromine-magnesium exchange of 2-benzylated 3,4,5-tribromopyrazole 1-oxides and subsequent halogen dance of the resulting monometalated intermediates was used to synthesize fused pyrazoloquinoline 1-oxides. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：7635 / 7644

页数：10

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