Systemic and Targeted Therapy for Biliary Tract Tumors and Primary Liver Tumors

被引：9

作者：

Thomas, Melanie Byrne ^{[1
]}

机构：

[1] Med Univ S Carolina, Coll Med, Hollings Canc Ctr, Charleston, SC 29425 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 23卷 / 02期

关键词：

Bile duct cancer cholangiocarcinoma; Hepatocellular carcinoma; Systemic therapy; Chemotherapy; Targeted therapies; PHASE-II TRIAL; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; GROWTH-FACTOR RECEPTOR; CHOLANGIOCARCINOMA CELL-GROWTH; GALLBLADDER CANCER-CELLS; BILE-DUCT; INTRAHEPATIC CHOLANGIOCARCINOMA; CHOLANGIOCELLULAR CARCINOMA; NUDE-MICE; C-MET;

D O I：

10.1016/j.soc.2013.11.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumors of the biliary tract and hepatocellular carcinoma (HOC) are complex tumors with heterogeneous carcinogenic mechanisms. Patients with hepatobiliary cancer have advanced disease and need systemic therapy to palliate symptoms and extend survival. Development of effective systemic therapy is a significant unmet medical need. It is hoped that current and future clinical trials will identify additional effective systemic agents, combination systemic therapies, and combined modality options. The HCC community needs validated biomarkers to help identify the patients who will benefit most from emerging treatment options.

引用

页码：369 / +

页数：15

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