Purine biosynthesis regulates mTORC1 by modulating Rheb GTPase activity

被引:0
|
作者
Unsal-Kacmaz, Kezi [1 ]
Emmanuel, Natasha [1 ]
Ragunathan, Shoba [1 ]
Shan, Qin [1 ]
Wang, Fang [1 ]
Giannakou, Andreas [1 ]
Huser, Nanni [1 ]
Jin, Guixian [1 ]
Myers, Jeremy [1 ]
Abraham, Robert T. [1 ]
机构
[1] Pfizer, Pearl River, NY USA
关键词
D O I
10.1158/1535-7163.TARG-17-B025
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B025
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays
    Shams, Raef
    Ito, Yoshihiro
    Miyatake, Hideyuki
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [32] UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle
    Gao, Hongbo
    Freeling, Jessica
    Wu, Penglong
    Liang, Ashley P.
    Wang, Xuejun
    Li, Yifan
    LIFE SCIENCES, 2019, 233
  • [33] Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
    Gnocchi, Davide
    Ellis, Ewa C. S.
    Johansson, Helene
    Eriksson, Mats
    Bruscalupi, Giovannella
    Steffensen, Knut R.
    Parini, Paolo
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 499
  • [34] mTORC1 activity negatively regulates human hair follicle growth and pigmentation
    Suzuki, Takahiro
    Cheret, Jeremy
    Scala, Fernanda Dinelli
    Akhundlu, Aysun
    Gherardini, Jennifer
    Demetrius, Dana-Lee
    O'Sullivan, James D. B.
    Kuka Epstein, Gorana
    Bauman, Alan J.
    Demetriades, Constantinos
    Paus, Ralf
    EMBO REPORTS, 2023, 24 (07)
  • [35] SPOP negatively regulates mTORC1 activity by ubiquitinating Sec13
    Yang, Yong
    Han, Yan-Chun
    Cao, Qi
    Wang, Xi
    Wei, Xiao-Dan
    Shang, Meng-Di
    Zhang, Xiao-Gang
    Li, Xiao
    Hu, Bin
    Tian, Cheng-Yang
    Yang, Zhen-Lin
    Liu, Ke-Hui
    Wang, Jiu-Qiang
    CELLULAR SIGNALLING, 2024, 116
  • [36] Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons
    Choi, Seunghyuk
    Sadra, Ali
    Kang, Jieun
    Ryu, Jae Ryun
    Kim, June Hoan
    Sun, Woong
    Huh, Sung-Oh
    EXPERIMENTAL NEUROBIOLOGY, 2019, 28 (02) : 172 - 182
  • [37] Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex
    Yasuda, Shin
    Sugiura, Hiroko
    Katsurabayashi, Shutaro
    Shimada, Tadayuki
    Tanaka, Hidekazu
    Takasaki, Kotaro
    Iwasaki, Katsunori
    Kobayashi, Toshiyuki
    Hino, Okio
    Yamagata, Kanato
    SCIENTIFIC REPORTS, 2014, 4
  • [38] mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis
    Buel, Gwen R.
    Kim, Sang Gyun
    Blenis, John
    CELL METABOLISM, 2013, 17 (05) : 633 - 635
  • [39] Rheb Negatively Regulates Cardiomyocyte Survival during Nutrient Starvation and Prolonged Ischemia through mTORC1 Activation and Inhibition of Autophagy
    Sciarretta, Sebastiano
    Zhai, Peiyong
    Sadoshima, Junichi
    CIRCULATION, 2010, 122 (21)
  • [40] Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding
    Amemiya, Yuna
    Ioi, Yuichiro
    Araki, Makoto
    Kontani, Kenji
    Maki, Masatoshi
    Shibata, Hideki
    Takahara, Terunao
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2025, 301 (02)