Purine biosynthesis regulates mTORC1 by modulating Rheb GTPase activity

被引：0
|
作者：
Unsal-Kacmaz, Kezi [1 ]
Emmanuel, Natasha [1 ]
Ragunathan, Shoba [1 ]
Shan, Qin [1 ]
Wang, Fang [1 ]
Giannakou, Andreas [1 ]
Huser, Nanni [1 ]
Jin, Guixian [1 ]
Myers, Jeremy [1 ]
Abraham, Robert T. [1 ]
机构：
[1] Pfizer, Pearl River, NY USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2018年 / 17卷 / 01期
关键词：
D O I：
10.1158/1535-7163.TARG-17-B025
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B025
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
    Yang, Haijuan
    Jiang, Xiaolu
    Li, Buren
    Yang, Hyo J.
    Miller, Meredith
    Yang, Angela
    Dhar, Ankita
    Pavletich, Nikola P.
    NATURE, 2017, 552 (7685) : 368 - +
  • [22] A small molecule inhibitor of Rheb selectively targets mTORC1 signaling
    Sarah J. Mahoney
    Sridhar Narayan
    Lisa Molz
    Lauren A. Berstler
    Seong A. Kang
    George P. Vlasuk
    Eddine Saiah
    Nature Communications, 9
  • [23] RHEB1 IS A KEY REGULATOR OF MTORC1 PATHWAY IN HEMATOPOIETIC SYSTEM
    Wang, Xiaomin
    Gao, Yanan
    Gao, Juan
    Li, Minghao
    Cheng, Tao
    Yuan, Weiping
    EXPERIMENTAL HEMATOLOGY, 2016, 44 (09) : S106 - S106
  • [24] Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
    Saci, Abdelhafid
    Cantley, Lewis C.
    Carpenter, Christopher L.
    MOLECULAR CELL, 2011, 42 (01) : 50 - 61
  • [25] Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity (vol 5, e11058, 201226)
    Carroll, Bernadette
    Maetzel, Dorothea
    Maddocks, Oliver D. K.
    Otten, Gisela
    Ratcliff, Matthew
    Smith, Graham R.
    Dunlop, Elaine A.
    Passos, Joao F.
    Davies, Owen Richard
    Jaenisch, Rudolf
    Tee, Andrew R.
    Sarkar, Sovan
    Korolchuk, Viktor I.
    ELIFE, 2020, 9
  • [26] Modulating Alzheimer's Disease by mTORC1 inhibition to augment lysosomal activity
    Lear, Travis
    Lockwood, Karina
    Boudreau, Aine
    Larsen, Mads
    Lin, Bo
    Sukoff-Rizzo, Stacey
    Liu, Yuan
    Finkel, Toren
    Chen, Bill
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (03) : S598 - S598
  • [27] Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
    Lu Deng
    Lei Chen
    Linlin Zhao
    Yan Xu
    Xiaoping Peng
    Xinbo Wang
    Lin Ding
    Jiali Jin
    Hongqi Teng
    Yanming Wang
    Weijuan Pan
    Fei Yu
    Lujian Liao
    Li Li
    Xin Ge
    Ping Wang
    Cell Research, 2019, 29 : 136 - 150
  • [28] Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
    Deng, Lu
    Chen, Lei
    Zhao, Linlin
    Xu, Yan
    Peng, Xiaoping
    Wang, Xinbo
    Ding, Lin
    Jin, Jiali
    Teng, Hongqi
    Wang, Yanming
    Pan, Weijuan
    Yu, Fei
    Liao, Lujian
    Li, Li
    Ge, Xin
    Wang, Ping
    CELL RESEARCH, 2019, 29 (02) : 136 - 150
  • [29] Architecture of human Rag GTPase heterodimers and their complex with mTORC1
    Anandapadamanaban, Madhanagopal
    Masson, Glenn R.
    Perisic, Olga
    Berndt, Alex
    Kaufman, Jonathan
    Johnson, Chris M.
    Santhanam, Balaji
    Rogala, Kacper B.
    Sabatini, David M.
    Williams, Roger L.
    SCIENCE, 2019, 366 (6462) : 203 - +
  • [30] An Autoinhibited Noncanonical Mechanism of GTP Hydrolysis by Rheb Maintains mTORC1 Homeostasis
    Mazhab-Jafari, Mohammad T.
    Marshall, Christopher B.
    Ishiyama, Noboru
    Ho, Jason
    Di Palma, Vanessa
    Stambolic, Vuk
    Ikura, Mitsuhiko
    STRUCTURE, 2012, 20 (09) : 1528 - 1539
12345