SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF N-SUBSTITUTED BENZIMIDAZOLES

被引：0
|
作者：
Jadhav, S. B. [1 ]
Shastri, R. A. [1 ]
Bagul, K. R. [1 ]
Gaikwad, K. V. [1 ]
机构：
[1] Milind Coll Sci, PG Dept Chem, Aurangabad 431002, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 18卷 / 03期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two series of benzimidazole derivatives were synthesized by the condensation of different 2-substituted benzimidazoles with 3-(2-chlorophenyl)-5-methylisoxazole-4-carbonylchloride (CMIC) and 3-(2,4-dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride (DCMIC). The synthesized compounds were characterized by IR, H-1 NMR, elemental analysis and their physical properties. The compounds were evaluated for their antibacterial and antifungal activity. All the compounds exhibited significant to moderate antibacterial and antifungal activities.
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页码：319 / 320
页数：2
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