Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

被引：31
|
作者：
Garner, Evan F. [1 ]
Beierle, Elizabeth A. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Surg, Div Pediat Surg, Birmingham, AL 35233 USA
来源：
CANCERS | 2016年 / 8卷 / 01期
关键词：
neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia; BONE-MARROW METASTASES; HIGH-RISK NEUROBLASTOMA; SIDE POPULATION CELLS; INITIATING CELLS; ALDEHYDE DEHYDROGENASE; INFLAMMATORY CELLS; PERIVASCULAR NICHE; CXCR4; EXPRESSION; NKT CELLS; PATHWAY;
D O I：
10.3390/cancers8010005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
引用
收藏
页数：13
相关论文
共 50 条
  • [41] TUMOR METASTASIS GENES IN NEUROBLASTOMA STEM CELLS
    Aktas, Safiye
    Ercetin, Pinar
    Altun, Zekiye
    Cubuk, Cankut
    Olgun, Nur
    PEDIATRIC BLOOD & CANCER, 2011, 57 (05) : 782 - 783
  • [42] Linking Tumor Microenvironment to Plasticity of Cancer Stem Cells: Mechanisms and Application in Cancer Therapy
    Zheng, Xiaobo
    Yu, Chune
    Xu, Mingqing
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [43] Mesenchymal stem cells in the tumor microenvironment (Review)
    Guan, Jian
    Chen, Jie
    BIOMEDICAL REPORTS, 2013, 1 (04) : 517 - 521
  • [44] Mesenchymal Stem Cells: Their Role in the Tumor Microenvironment
    Idarraga, Jhon Alexander
    Munera, Luz Marina Restrepo
    TISSUE ENGINEERING PART B-REVIEWS, 2023, 29 (06) : 681 - 691
  • [45] The relationship of TMEM (tumor microenvironment of metastasis) doorways with breast cancer stem cells
    Kim, Gina
    Sharma, Ved P.
    Bandyopadhyaya, Gargi
    Grunblatt, Eli
    Roy, Sweta
    Agi, Nathan
    Tang, Binwu
    Adler, Esther
    Jones, Joan
    Karagiannis, George S.
    Ye, Xianjun
    Entenberg, David
    Goswami, Sumanta
    Wakefield, Lalage
    Condeelis, John S.
    Oktay, Maja H.
    CANCER RESEARCH, 2020, 80 (16)
  • [46] Cancer Stem Cells, Bone and Tumor Microenvironment: Key Players in Bone Metastases
    Roato, Ilaria
    Ferracini, Riccardo
    CANCERS, 2018, 10 (02)
  • [47] Brain tumors: Cancer stem-like cells interact with tumor microenvironment
    Liu, Hai-Long
    Wang, Ya-Nan
    Feng, Shi-Yu
    WORLD JOURNAL OF STEM CELLS, 2020, 12 (12): : 1439 - 1454
  • [48] Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells
    Hajizadeh, Farnaz
    Okoye, Isobel
    Esmaily, Maryam
    Chaleshtari, Mitra Ghasemi
    Masjedi, Ali
    Azizi, Gholamreza
    Irandoust, Mahzad
    Ghalamfarsa, Ghasem
    Jadidi-Niaragh, Farhad
    LIFE SCIENCES, 2019, 237
  • [49] Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?
    Krueger, Timothy E.
    Thorek, Daniel L. J.
    Meeker, Alan K.
    Isaacs, John T.
    Brennen, W. Nathaniel
    PROSTATE, 2019, 79 (03): : 320 - 330
  • [50] Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review
    Wang, Kai-Hung
    Ding, Dah-Ching
    TZU CHI MEDICAL JOURNAL, 2023, 35 (01): : 24 - 30
12345