Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

被引：31
|
作者：
Garner, Evan F. [1 ]
Beierle, Elizabeth A. [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Surg, Div Pediat Surg, Birmingham, AL 35233 USA
来源：
CANCERS | 2016年 / 8卷 / 01期
关键词：
neuroblastoma; cancer stem cell; cancer-associated fibroblasts; hypoxia; BONE-MARROW METASTASES; HIGH-RISK NEUROBLASTOMA; SIDE POPULATION CELLS; INITIATING CELLS; ALDEHYDE DEHYDROGENASE; INFLAMMATORY CELLS; PERIVASCULAR NICHE; CXCR4; EXPRESSION; NKT CELLS; PATHWAY;
D O I：
10.3390/cancers8010005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
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页数：13
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