Design, synthesis and anticonvulsant activity of some newer 3H-quinazolin-4-one derivatives

被引：0

作者：

Amir, Mohd ^{[1
]}

Ali, Israr ^{[1
]}

Hassan, Mohd Zaheen ^{[1
]}

机构：

[1] Hamdard Univ, Dept Pharmaceut Chem, Fac Pharm, New Delhi 110062, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 05期

关键词：

Anticonvulsants; neuroprotectives; quinazolinone; GABA; QUINAZOLINONE; EPILEPSY; RATS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the present investigation, a series of 2-[2-(aryl)-2-oxo-ethylsulfanyl]-3-(aryl/propyl)-3H-quinazolin-4-ones have been synthesized and tested for their potential against seizures in mice. All the newly synthesized compounds show moderate to high protection against 6 Hz partial seizure with compound 2b, 2-(2-oxo-2-p-tolyl-ethylsulfanyl)-3-phenyl-3H-quinazolin-4-one emerging as the most active anticonvulsant agent endowed with neuroprotective effect against NMDA and kainate induced excitotoxicity. The results of whole brain GABA assay indicates that the seizure protective activity of 2b can be either due to the increased brain GABA level or due to neuroprotective action.

引用

页码：597 / 604

页数：8

共 50 条

[41] Design, synthesis, and pharmacological characterization of some 2-substituted-3-phenyl-quinazolin-4(3H)-one derivatives as phosphodiesterase inhibitors
Amin, Kamilia M.
Hegazy, Gehan H.
George, Riham F.
Ibrahim, Nahla R.
Mohamed, Nada M.
ARCHIV DER PHARMAZIE, 2021, 354 (09)
[42] SYNTHESIS OF NOVEL 2-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YLSULFINYLMETHYL)-3H-QUINAZOLIN-4-ONE
Reddy, B. Srinivasa
Naidu, A.
Dubey, P. K.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2012, 187 (05) : 598 - 605
[43] New straightforward synthesis of 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one
Chen, Wei-Min
Wan, Shan-He
SYNTHETIC COMMUNICATIONS, 2007, 37 (1-3) : 53 - 61
[44] SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 4-ARYL-4-IMIDAZOLINE-2-ONE DERIVATIVES
CALIS, U
DALKARA, S
ERTAN, M
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1992, 42-1 (05): : 592 - 594
[45] SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 2(3H)-BENZOXAZOLONE DERIVATIVES
DALKARA, S
CALIS, U
SUNAL, R
JOURNAL DE PHARMACIE DE BELGIQUE, 1988, 43 (05) : 372 - 378
[46] Synthesis and antimicrobial activity of some new quinazolin-4(3H)-one derivatives (Retraction of vol 15, pg 95, 2011)
Kadi, Adnan A.
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2013, 17 (04) : 425 - 425
[47] Synthesis and antimicrobial screening of some new N3-substituted derivatives of quinazolin-4(3H)-one
Patil, Suresh
Jadhav, S. D.
Patil, B. M.
Deshmukh, M. B.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2014, 91 (01) : 113 - 116
[48] In vitro evaluation of the antibacterial and antifungal activity of some new pyrazolyl-quinazolin-4(3H)-one derivatives
Patel, Navin B.
Patel, Jaymin C.
Barat, Gaman G.
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (02) : 229 - 238
[49] In vitro evaluation of the antibacterial and antifungal activity of some new pyrazolyl-quinazolin-4(3H)-one derivatives
Navin B. Patel
Jaymin C. Patel
Gaman G. Barat
Medicinal Chemistry Research, 2012, 21 : 229 - 238
[50] ELECTROREDUCTION OF SOME POTENTIAL ANTIMICROBIAL THIOSEMICARBAZIDE DERIVATIVES OF QUINAZOLIN-4(3H)-ONE
ISMAIL, MI
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1992, (04): : 585 - 589

← 1 2 3 4 5 →