Design, synthesis and anticonvulsant activity of some newer 3H-quinazolin-4-one derivatives

被引：0
|
作者：
Amir, Mohd [1 ]
Ali, Israr [1 ]
Hassan, Mohd Zaheen [1 ]
机构：
[1] Hamdard Univ, Dept Pharmaceut Chem, Fac Pharm, New Delhi 110062, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 05期
关键词：
Anticonvulsants; neuroprotectives; quinazolinone; GABA; QUINAZOLINONE; EPILEPSY; RATS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present investigation, a series of 2-[2-(aryl)-2-oxo-ethylsulfanyl]-3-(aryl/propyl)-3H-quinazolin-4-ones have been synthesized and tested for their potential against seizures in mice. All the newly synthesized compounds show moderate to high protection against 6 Hz partial seizure with compound 2b, 2-(2-oxo-2-p-tolyl-ethylsulfanyl)-3-phenyl-3H-quinazolin-4-one emerging as the most active anticonvulsant agent endowed with neuroprotective effect against NMDA and kainate induced excitotoxicity. The results of whole brain GABA assay indicates that the seizure protective activity of 2b can be either due to the increased brain GABA level or due to neuroprotective action.
引用
收藏
页码：597 / 604
页数：8
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