Persistent sodium current properties in hippocampal CM pyramidal neurons of young and adult rats

被引：9

作者：

Lunko, Oleksii ^{[1
]}

Isaev, Dmytro ^{[1
,2
]}

Maximyuk, Oleksandr ^{[1
,2
]}

Ivanchick, Gleb ^{[1
]}

Sydorenko, Vadym ^{[1
]}

Krishtal, Oleg ^{[1
,2
]}

Isaeva, Elena ^{[1
]}

机构：

[1] AA Bogomolets Physiol Inst, Dept Cellular Membranol, UA-01024 Kiev, Ukraine

[2] State Key Lab Mol & Cellular Biol, UA-01024 Kiev, Ukraine

来源：

NEUROSCIENCE LETTERS | 2014年 / 559卷

关键词：

Persistent tetrodotoxin-sensitive sodium; current; Hippocampal CA1 pyramidal neurons; Postnatal development; MEMBRANE-POTENTIAL OSCILLATIONS; NEOCORTICAL NEURONS; LOW-THRESHOLD; CORTEX; CHANNELS; SUBUNITS;

D O I：

10.1016/j.neulet.2013.11.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Persistent tetrodotoxin-sensitive sodium current (I-NaP) Plays an important role in cellular and neuronal network excitability in physiological conditions and under different pathological circumstances. However, developmental changes in I-NaP properties remain largely unclear. In the present study using whole cell patch clamp technique we evaluated I-NaP Properties in CA1 hippocampal pyramidal neurons isolated from young (postnatal day (P) 12-16) and adult (P60-75) rats. We show that the I-NaP density is substantially larger in the adult group. Although I-NaP inactivation characteristics were found to be similar in both groups, voltage dependence of I-NaP activation is shifted to more negative membrane potentials (young: the basal membrane sodium conductivity in the mature hippocampus. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：30 / 33

页数：4

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