Persistent sodium current properties in hippocampal CM pyramidal neurons of young and adult rats

被引：9
|
作者：
Lunko, Oleksii [1 ]
Isaev, Dmytro [1 ,2 ]
Maximyuk, Oleksandr [1 ,2 ]
Ivanchick, Gleb [1 ]
Sydorenko, Vadym [1 ]
Krishtal, Oleg [1 ,2 ]
Isaeva, Elena [1 ]
机构：
[1] AA Bogomolets Physiol Inst, Dept Cellular Membranol, UA-01024 Kiev, Ukraine
[2] State Key Lab Mol & Cellular Biol, UA-01024 Kiev, Ukraine
来源：
NEUROSCIENCE LETTERS | 2014年 / 559卷
关键词：
Persistent tetrodotoxin-sensitive sodium; current; Hippocampal CA1 pyramidal neurons; Postnatal development; MEMBRANE-POTENTIAL OSCILLATIONS; NEOCORTICAL NEURONS; LOW-THRESHOLD; CORTEX; CHANNELS; SUBUNITS;
D O I：
10.1016/j.neulet.2013.11.035
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Persistent tetrodotoxin-sensitive sodium current (I-NaP) Plays an important role in cellular and neuronal network excitability in physiological conditions and under different pathological circumstances. However, developmental changes in I-NaP properties remain largely unclear. In the present study using whole cell patch clamp technique we evaluated I-NaP Properties in CA1 hippocampal pyramidal neurons isolated from young (postnatal day (P) 12-16) and adult (P60-75) rats. We show that the I-NaP density is substantially larger in the adult group. Although I-NaP inactivation characteristics were found to be similar in both groups, voltage dependence of I-NaP activation is shifted to more negative membrane potentials (young: the basal membrane sodium conductivity in the mature hippocampus. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：30 / 33
页数：4
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