Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c ]coumarins

被引：12

作者：

Olyaei, Abolfazl ^{[1
]}

Saraei, Mahnaz ^{[1
]}

Khoeiniha, Reyhaneh ^{[1
]}

机构：

[1] Payame Noor Univ, Dept Chem, POB 19395-4697, Tehran, Iran

来源：

SYNLETT | 2018年 / 29卷 / 12期

关键词：

furo[3,2-c ]coumarin; phenylglyoxal monohydrate; 4-hydroxycoumarin; heteroarylamine; multicomponent reaction; SOLVENT-FREE CONDITIONS; EFFICIENT; FUROCOUMARINS; COUMARINS; CASCADE; WATER; HETEROCYCLES; CYCLIZATION; ANNULATION; RELEASE;

D O I：

10.1055/s-0036-1591582

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c ]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

引用

页码：1589 / 1592

页数：4

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