Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c ]coumarins

被引：12
|
作者：
Olyaei, Abolfazl [1 ]
Saraei, Mahnaz [1 ]
Khoeiniha, Reyhaneh [1 ]
机构：
[1] Payame Noor Univ, Dept Chem, POB 19395-4697, Tehran, Iran
来源：
SYNLETT | 2018年 / 29卷 / 12期
关键词：
furo[3,2-c ]coumarin; phenylglyoxal monohydrate; 4-hydroxycoumarin; heteroarylamine; multicomponent reaction; SOLVENT-FREE CONDITIONS; EFFICIENT; FUROCOUMARINS; COUMARINS; CASCADE; WATER; HETEROCYCLES; CYCLIZATION; ANNULATION; RELEASE;
D O I：
10.1055/s-0036-1591582
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c ]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.
引用
收藏
页码：1589 / 1592
页数：4
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