Synthesis and Characterization of Poly(Methyl Methacrylate) PMMA and Evaluation of Cytotoxicity for Biomedical Application

被引：34
|
作者：
Feuser, Paulo E. [1 ]
Gaspar, Pamela C. [2 ]
Ricci-Junior, Eduardo [3 ]
da Silva, Maria C. S. [2 ]
Nele, Marcio [4 ]
Sayer, Claudia [1 ]
de Araujo, Pedro. H. H. [1 ]
机构：
[1] Univ Fed Santa Catarina, Dept Chem Engn, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Dept Clin Anal, BR-88040900 Florianopolis, SC, Brazil
[3] Univ Fed Rio de Janeiro, Coll Pharm, BR-21941 Rio De Janeiro, Brazil
[4] Univ Fed Rio de Janeiro, Sch Chem, BR-21941 Rio De Janeiro, Brazil
来源：
MACROMOLECULAR SYMPOSIA | 2014年 / 343卷 / 01期
关键词：
biomaterials; miniemulsion polymerization; nanoparticles; stability; MINIEMULSION POLYMERIZATION; DRUG-DELIVERY; NANOPARTICLES; STABILITY; NANOEMULSIONS;
D O I：
10.1002/masy.201300194
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The objective this work was the synthesis, characterization and evaluation of cytotoxicity poly(methyl methacrylate), PMMA, nanoparticles (NPs) produced using miniemulsion polymerization technique adopting azobisisobutylonitrile (AIBN) as initiator and biocompatible and biodegradable surfactant, lecithin and co-stabilizer, miglyol 812 The NPs showed high stability during one year and an average diameter of 89 nm with polydispersity index of 0.11 and a zeta potential -48 mV. The PMMA NPs were tested for cytotoxicity in acute monocytic leukemia cells (THP1) and in human lung adenocarcinoma cells (A549). The PMMA NPs did not show any adverse effect on cell viability indicating their potential to encapsulate antitumor agents.
引用
收藏
页码：65 / 69
页数：5
相关论文
共 50 条
  • [31] The Synthesis and Characterization of Poly(methyl methacrylate-tourmaline acrylate)
    Hu, Yingmo
    Chen, Xubo
    Li, Yunhua
    ADVANCES IN MATERIALS SCIENCE AND ENGINEERING, 2016, 2016
  • [32] Synthesis at the nanoscale of ZnO into poly(methyl methacrylate) and its characterization
    Khan, Majid
    Chen, Mingming
    Wei, Chengsha
    Tao, Jiaojiao
    Huang, Ningdong
    Qi, Zeming
    Li, Liangbin
    APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, 2014, 117 (03): : 1085 - 1093
  • [33] Synthesis and characterization of poly(methyl methacrylate)-grafted silica microparticles
    Derouet, Daniel
    Thuc, Chi Nhan Ha
    JOURNAL OF APPLIED POLYMER SCIENCE, 2008, 109 (04) : 2113 - 2127
  • [34] Synthesis and Characterization of Bagasse Poly(methyl methacrylate) Graft Copolymer
    Sarvi, I.
    Pourjavadi, A.
    Aghaei, M. A. Noei
    MACROMOLECULAR SYMPOSIA, 2008, 274 : 49 - 54
  • [35] Synthesis and Characterization of In Situ Polymerized Poly(methyl methacrylate)-Cerium Molybdate Nanocomposite for Electroanalytical Application
    Khan, Asif Ali
    Paquiza, Leena
    JOURNAL OF APPLIED POLYMER SCIENCE, 2013, 127 (05) : 3737 - 3748
  • [36] Synthesis and characterization of in situ polymerized poly(methyl methacrylate)-cerium molybdate nanocomposite for electroanalytical application
    Khan, Asif Ali
    Paquiza, Leena
    Khan, A.A. (asifkhan42003@yahoo.com), 1600, John Wiley and Sons Inc (127): : 3737 - 3748
  • [37] Degradation of poly(methyl methacrylate) (PMMA) with aluminum nitride and alumina
    Lee, YM
    Viswanath, DS
    POLYMER ENGINEERING AND SCIENCE, 2000, 40 (11): : 2332 - 2341
  • [38] Functionalization of poly(methyl methacrylate) (PMMA) as a substrate for DNA microarrays
    Fixe, F
    Dufva, M
    Telleman, P
    Christensen, CBV
    NUCLEIC ACIDS RESEARCH, 2004, 32 (01) : e9
  • [39] ANIONIC POLY(METHYL METHACRYLATE) (PMMA) MEMBRANE FOR RAPID DIALYSIS
    ONO, T
    IWAMOTO, N
    KATAOKA, H
    TANIGUCHI, Y
    KIMURA, M
    KUNITOMO, T
    TRANSACTIONS AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS, 1982, 28 : 38 - 42
  • [40] Electrospinning of cyclodextrin functionalized poly(methyl methacrylate) (PMMA) nanofibers
    Uyar, Tamer
    Balan, Abidin
    Toppare, Levent
    Besenbacher, Flemming
    POLYMER, 2009, 50 (02) : 475 - 480
12345