Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

被引：55

作者：

Feng, Y

Niu, TH

Xu, X

Chen, CZ

Li, QF

Qian, RL

Wang, GY

Xu, XP

机构：

[1] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA

[2] Beijing Univ, Affiliated Hosp 3, Div Endocrinol, Beijing, Peoples R China

[3] Beijing Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China

[4] Beijing Univ, Affiliated Hosp 1, Div Endocrinol, Beijing, Peoples R China

来源：

DIABETES | 2002年 / 51卷 / 06期

关键词：

D O I：

10.2337/diabetes.51.6.1986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(1)(2) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

引用

页码：1986 / 1988

页数：3

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