Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

被引：55
|
作者：
Feng, Y
Niu, TH
Xu, X
Chen, CZ
Li, QF
Qian, RL
Wang, GY
Xu, XP
机构：
[1] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA
[2] Beijing Univ, Affiliated Hosp 3, Div Endocrinol, Beijing, Peoples R China
[3] Beijing Univ, Ctr Ecogenet & Reprod Hlth, Beijing, Peoples R China
[4] Beijing Univ, Affiliated Hosp 1, Div Endocrinol, Beijing, Peoples R China
来源：
DIABETES | 2002年 / 51卷 / 06期
关键词：
D O I：
10.2337/diabetes.51.6.1986
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (chi(1)(2) = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
引用
收藏
页码：1986 / 1988
页数：3
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