Fast and easy access to efficient bifunctional chelators for MRI applications

被引：44

作者：

Gugliotta, Giuseppe ^{[1
]}

Botta, Mauro ^{[1
]}

Giovenzana, Giovanni Battista ^{[2
]}

Tei, Lorenzo ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15121 Alessandria, Italy

[2] Univ Piemonte Orientale, DiSCAFF & DFB Ctr, I-28100 Novara, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 13期

关键词：

Molecular imaging; Magnetic resonance imaging; Gd(III) contrast agents; Bifunctional chelates; PROMOTED O-ALKYLATION; CONTRAST AGENTS; ETHER SYNTHESIS; TERT-BUTYL; ACID; COMPLEXES; ALCOHOLS; ESTERS; DYNAMICS;

D O I：

10.1016/j.bmcl.2009.05.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd-III complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3442 / 3444

页数：3

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