Fast and easy access to efficient bifunctional chelators for MRI applications

被引：44
|
作者：
Gugliotta, Giuseppe [1 ]
Botta, Mauro [1 ]
Giovenzana, Giovanni Battista [2 ]
Tei, Lorenzo [1 ]
机构：
[1] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15121 Alessandria, Italy
[2] Univ Piemonte Orientale, DiSCAFF & DFB Ctr, I-28100 Novara, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 13期
关键词：
Molecular imaging; Magnetic resonance imaging; Gd(III) contrast agents; Bifunctional chelates; PROMOTED O-ALKYLATION; CONTRAST AGENTS; ETHER SYNTHESIS; TERT-BUTYL; ACID; COMPLEXES; ALCOHOLS; ESTERS; DYNAMICS;
D O I：
10.1016/j.bmcl.2009.05.024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd-III complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3442 / 3444
页数：3
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