Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

被引：54
|
作者：
Karlberg, Tobias [1 ]
Langelier, Marie-France [2 ]
Pascal, John M. [2 ]
Schuler, Hervvig [1 ]
机构：
[1] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 06期
基金：
瑞典研究理事会;
关键词：
ADP-ribosylation; DNA repair; Glycohydrolase; Macro domain; Signaling pathways; Transferase; APOPTOSIS-INDUCING FACTOR; REPEAT-BINDING FACTOR-1; STERILE ALPHA-MOTIF; CRYSTAL-STRUCTURE; ADP-RIBOSE; NAD(+)-DEPENDENT DEACETYLASE; CATALYTIC FRAGMENT; SUBSTRATE-BINDING; CONSERVED DOMAIN; PROTEIN-KINASE;
D O I：
10.1016/j.mam.2013.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1088 / 1108
页数：21
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