Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

被引：54

作者：

Karlberg, Tobias ^{[1
]}

Langelier, Marie-France ^{[2
]}

Pascal, John M. ^{[2
]}

Schuler, Hervvig ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Biochem & Mol Biol, Philadelphia, PA 19107 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 06期

基金：

瑞典研究理事会;

关键词：

ADP-ribosylation; DNA repair; Glycohydrolase; Macro domain; Signaling pathways; Transferase; APOPTOSIS-INDUCING FACTOR; REPEAT-BINDING FACTOR-1; STERILE ALPHA-MOTIF; CRYSTAL-STRUCTURE; ADP-RIBOSE; NAD(+)-DEPENDENT DEACETYLASE; CATALYTIC FRAGMENT; SUBSTRATE-BINDING; CONSERVED DOMAIN; PROTEIN-KINASE;

D O I：

10.1016/j.mam.2013.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1088 / 1108

页数：21

共 50 条

[21] INHIBITION OF POLY(ADP-RIBOSE) POLYMERASE BY ARGININE SPECIFIC MONO(ADP-RIBOSYL)ATION
ALVAREZGONZALEZ, R
MARTINEZCADENA, MG
STANLEY, SJ
MOSS, J
FASEB JOURNAL, 1992, 6 (01): : A282 - A282
[22] MONO(ADP-RIBOSYL)ATION OF POLY(ADP-RIBOSE)POLYMERASE BY CHOLERA-TOXIN
MARTINEZ, M
PRICE, SR
MOSS, J
ALVAREZGONZALEZ, R
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (03) : 1412 - 1418
[23] CONVERSION OF ADP-RIBOSE TO 5'-AMP BY ALKALINE TREATMENT AND ITS USE FOR AN OPTICAL QUANTITATION OF MONO AND POLY(ADP-RIBOSE) RESIDUES IN MICROMOLAR RANGE
GOEBEL, M
STONE, PR
LENGYEL, H
HILZ, H
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1977, 358 (01): : 13 - 21
[24] Poly(ADP-ribose): A signaling molecule in different paradigms of cell death
Aredia, Francesca
Scovassi, Anna Ivana
BIOCHEMICAL PHARMACOLOGY, 2014, 92 (01) : 157 - 163
[25] Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
Dahl, Markus
Maturi, Varun
Lonn, Peter
Papoutsoglou, Panagiotis
Zieba, Agata
Vanlandewijck, Michael
van der Heide, Lars P.
Watanabe, Yukihide
Soderberg, Ola
Hottiger, Michael O.
Heldin, Carl-Henrik
Moustakas, Aristidis
PLOS ONE, 2014, 9 (08):
[26] Poly(ADP-ribose) acts as a signaling molecule during hydrogen peroxide-mediated osteogenic differentiation
Robaszkiewicz, A.
Erdelyi, K.
Kovacs, K.
Kovacs, I.
Bai, P.
Rajnavolgyi, E.
Virag, L.
FEBS JOURNAL, 2013, 280 : 444 - 444
[27] Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
Endres, M
Wang, ZQ
Namura, S
Waeber, C
Moskowitz, MA
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (11): : 1143 - 1151
[28] SIMULTANEOUS DETERMINATION OF MONO(ADP-RIBOSE) AND POLY(ADP-RIBOSE) INVIVO BY TRITIUM LABELING AND DIRECT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION
HAKAM, A
MCLICK, J
KUN, E
JOURNAL OF CHROMATOGRAPHY, 1986, 359 : 275 - 284
[29] A ROLE OF NICOTINAMIDE, TRIGONELLINE AND POLY(ADP-RIBOSE)POLYMERASE IN STRESS SIGNALING IN PLANTS
BERGLUND, T
HENKOW, L
STRID, A
RYDSTROM, J
OHLSSON, AB
JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 499 - 499
[30] DIFFERENTIAL EFFECTS OF HETEROCYCLIC AMINES ON POLY(ADP-RIBOSE) POLYMERASE-1 AND MONO-ADP-RIBOSYLTRANSFERASE A
Banasik, M.
Stedeford, T.
Strosznajder, R. P.
Hsu, C-H
Tanaka, S.
Ueda, K.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2006, 57 : 15 - 22

← 1 2 3 4 5 →