Microwave-Assisted Synthesis of 2-Aryl and 2,5-Diarylthiophene Derivatives via Suzuki-Miyaura Cross-Coupling Using Novel Palladium Complex as a Catalyst

A novel phosphine-free pyrimidine-based palladium(II) complex have been synthesized from easily accessible starting materials and its ability to be a catalyst for cross-coupling reactions namely, Suzuki-Miyaura (SMC) has been investigated. The structure of the new formamidinyl pyrimidine-based complex has been elucidated by using spectroscopic as well as physical characterization techniques. The novel palladium(II) complex showed its applicability as a catalyst for SMC of 2-bromothiophene and 2,5-dibromothiophene with arylboronic acids under conventional and microwaves irradiation conditions. The developed catalytic system exhibited reasonable catalytic activity to obtain 2-aryl and 2,5-diarylthiophene derivatives using mild reaction conditions.