Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

被引：51

作者：

Nielsen, Dennis S. ^{[1
]}

Krych, Lukasz ^{[1
]}

Buschard, Karsten ^{[2
]}

Hansen, Camilla H. F. ^{[3
]}

Hansen, Axel K. ^{[3
]}

机构：

[1] Univ Copenhagen, Fac Sci, Dept Food Sci, DK-1958 Frederiksberg C, Denmark

[2] Rigshosp, Bartholin Inst, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, DK-1871 Frederiksberg C, Denmark

来源：

FEBS LETTERS | 2014年 / 588卷 / 22期

关键词：

Type; 1; diabetes; Etiology; Diet; Gut microbiota; SEGMENTED FILAMENTOUS BACTERIA; BETA-CELL AUTOIMMUNITY; GLUTEN-FREE; INTESTINAL MICROBIOTA; INCREASED RISK; VITAMIN-D; AKKERMANSIA-MUCINIPHILA; ISLET AUTOIMMUNITY; HYGIENE HYPOTHESIS; YOUNG-CHILDREN;

D O I：

10.1016/j.febslet.2014.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting beta-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4234 / 4243

页数：10

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