Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes

被引：51
|
作者：
Nielsen, Dennis S. [1 ]
Krych, Lukasz [1 ]
Buschard, Karsten [2 ]
Hansen, Camilla H. F. [3 ]
Hansen, Axel K. [3 ]
机构：
[1] Univ Copenhagen, Fac Sci, Dept Food Sci, DK-1958 Frederiksberg C, Denmark
[2] Rigshosp, Bartholin Inst, DK-2100 Copenhagen, Denmark
[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, DK-1871 Frederiksberg C, Denmark
来源：
FEBS LETTERS | 2014年 / 588卷 / 22期
关键词：
Type; 1; diabetes; Etiology; Diet; Gut microbiota; SEGMENTED FILAMENTOUS BACTERIA; BETA-CELL AUTOIMMUNITY; GLUTEN-FREE; INTESTINAL MICROBIOTA; INCREASED RISK; VITAMIN-D; AKKERMANSIA-MUCINIPHILA; ISLET AUTOIMMUNITY; HYGIENE HYPOTHESIS; YOUNG-CHILDREN;
D O I：
10.1016/j.febslet.2014.04.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Type 1 diabetes (T1D) is an autoimmune disease ultimately leading to destruction of insulin secreting beta-cells in the pancreas. Genetic susceptibility plays an important role in T1D etiology, but even mono-zygotic twins only have a concordance rate of around 50%, underlining that other factors than purely genetic are involved in disease development. Here we review the influence of dietary and environmental factors on T1D development in humans as well as animal models. Even though data are still inconclusive, there are strong indications that gut microbiota dysbiosis plays an important role in T1D development and evidence from animal models suggests that gut microbiota manipulation might prove valuable in future prevention of T1D in genetically susceptible individuals. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：4234 / 4243
页数：10
相关论文
共 50 条
  • [21] Gut microbiota and immunopathogenesis of diabetes mellitus type 1 and 2
    Wang, Fei
    Zhang, Chunfang
    Zeng, Qiang
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2016, 21 : 900 - 906
  • [22] Gut microbiota profiling in Han Chinese with type 1 diabetes
    Huang, Yun
    Li, Si-Cheng
    Hu, Ji
    Ruan, Hai-Bin
    Guo, He-Ming
    Zhang, Hong-Hong
    Wang, Xin
    Pei, Yu-Fang
    Pan, Yang
    Fang, Chen
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2018, 141 : 256 - 263
  • [23] Host gene effects on gut microbiota in type 1 diabetes
    Guo, Keyu
    Huang, Juan
    Zhou, Zhiguang
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2022, 50 (03) : 1133 - 1142
  • [24] THE ROLE OF THE GUT MICROBIOTA IN THE DEVELOPMENT OF TYPE 1 DIABETES MELLITUS
    Ibraginnoval, Liudmila I.
    Kolpakova, Evgenia A.
    Dzagakhova, Agunda, V
    Egshatyan, Lilit, V
    Pokrovskaya, Elena, V
    Derevyanko, Olga S.
    Nikonova, Tatiana, V
    DIABETES MELLITUS, 2021, 24 (01): : 62 - 69
  • [25] Targeted Regulation of Dietary Factors on Gut Microbiota
    膳食因子对肠道菌群的靶向性调节
    1600, Chinese Institute of Food Science and Technology (21): : 1 - 8
  • [26] The influence of antibiotics and dietary components on gut microbiota
    Dudek-Wicher, Ruth K.
    Junka, Adam
    Bartoszewicz, Marzenna
    GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY, 2018, 13 (02): : 85 - 92
  • [27] Assessing the Influence of Dietary History on Gut Microbiota
    Bo Yang
    Chang Ye
    Bingyu Yan
    Xionglei He
    Ke Xing
    Current Microbiology, 2019, 76 : 237 - 247
  • [28] Assessing the Influence of Dietary History on Gut Microbiota
    Yang, Bo
    Ye, Chang
    Yan, Bingyu
    He, Xionglei
    Xing, Ke
    CURRENT MICROBIOLOGY, 2019, 76 (02) : 237 - 247
  • [29] Characterization of Gut Microbiota in Lean Type 1 Diabetes, Overweight Type 1 Diabetes, and Healthy Controls
    Gowda, Shashikala B.
    Farrell, Ryan M.
    Macleish, Sarah A.
    Salem, Iman
    Retuerto, Mauricio A.
    Ghannoum, Mahmoud A.
    DIABETES, 2020, 69
  • [30] Dietary fibers as emerging nutritional factors against diabetes: focus on the involvement of gut microbiota
    Gowd, Vemana
    Xie, Lianghua
    Zheng, Xiaodong
    Chen, Wei
    CRITICAL REVIEWS IN BIOTECHNOLOGY, 2019, 39 (04) : 524 - 540
12345