Copper-Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition

被引：125

作者：

Gutsmiedl, Katrin ^{[1
]}

Wirges, Christian T. ^{[1
]}

Ehmke, Veronika ^{[1
]}

Carell, Thomas ^{[1
]}

机构：

[1] Univ Munich, Ctr Integrat Prot Sci, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 11期

关键词：

AZIDE-ALKYNE CYCLOADDITION; FREE TRIAZOLE FORMATION; BENZONITRILE OXIDE; CHEMISTRY; LIGATION; BIOCONJUGATION; NUCLEOTIDES; POLYMER; SINGLE; TOOL;

D O I：

10.1021/ol9005322

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nitrile oxides react smoothly and rapidly with norbornene-modified DNA in a copper-free click reaction. The reaction allows high density functionalization of oligodeoxyribonucleotides (ODNs) with a large variety of molecules directly on solid supports and even in synthesizers without the need for an additional catalyst.

引用

页码：2405 / 2408

页数：4

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