Spiro Isoxazolines via Nitrile Oxide 1,3-Dipolar Cycloaddition Reactions

被引：0
|
作者：
Savage, G. Paul [1 ]
机构：
[1] CSIRO Mol & Hlth Technol, Ian Wark Lab, Clayton, Vic 3168, Australia
来源：
CURRENT ORGANIC CHEMISTRY | 2010年 / 14卷 / 14期
关键词：
Nitrile oxide; dipolar cycloaddition; heterocycle; spiro; exocyclic methylene; isoxazoline; SEQUENTIAL REARRANGEMENT-ANNULATION; NICOTINIC ACETYLCHOLINE-RECEPTORS; CARBOCYCLIC RING-CLOSURE; FACE SELECTIVITY; 3,5-DICHLORO-2,4,6-TRIMETHYLBENZONITRILE OXIDE; 5-SUBSTITUTED ADAMANTANE-2-THIONES; REGIOSELECTIVE CYCLOADDITION; DIASTEREOSELECTIVE SYNTHESIS; THERMAL REARRANGEMENT; BENZONITRILE OXIDES;
D O I：
10.2174/138527210791616812
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 1,3-dipolar cycloaddition reaction of nitrile oxides with carbon dipolarophiles is a versatile and powerful synthetic method to prepare isoxazolines. In particular nitrile oxide cycloaddition reactions with exocyclic methylene or alkylidene compounds generally proceed regioselectively leading to spiro heterocyclic compounds. This review deals with progress in the field of nitrile oxide cycloaddition chemistry for the synthesis of spiro isoxazolines.
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收藏
页码：1478 / 1499
页数：22
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