ENANTIOSELECTIVE SYNTHESIS OF 2-ISOXAZOLINES VIA ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION OF NITRILE OXIDE TO ACHIRAL ALLYL ALCOHOL

被引：70
|
作者：
UKAJI, Y
SADA, K
INOMATA, K
机构：
来源：
CHEMISTRY LETTERS | 1993年 / 11期
关键词：
D O I：
10.1246/cl.1993.1847
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The asymmetric 1,3-dipolar cycloaddition of a nitrile oxide to an achiral allyl alcohol was achieved by the use of (R,R)-diisopropyl tartrate as a chiral auxiliary. Treatment of the allyl alcohol with diethylzinc and the tartrate, followed by the addition of diethylzinc and a hydroximoyl chloride, afforded the corresponding (R)-2-isoxazolines with excellent enantioselectivity.
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页码：1847 / 1850
页数：4
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