Bioactive Tyrosine-Derived Cytochalasins from Fungus Eutypella sp D-1

被引：32

作者：

Liu, Jing-Tang ^{[1
]}

Hu, Bo ^{[1
]}

Gao, Yun ^{[1
]}

Zhang, Jian-Peng ^{[1
]}

Jiao, Bing-Hua ^{[1
]}

Lu, Xiao-Ling ^{[1
]}

Liu, Xiao-Yu ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Biochem & Mol Biol, Coll Basic Med Sci, Shanghai, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2014年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Eutypella; Cytochalasins; Arctic fungi; Fungi; Cytotoxic activity; ACTIN; METABOLITES;

D O I：

10.1002/cbdv.201300218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new cytochalasins Z(24), Z(25), Z(26) (1-3, resp.) and one known compound, scoparasin B (4), were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of the Arctic. The structures of 1-3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF-7 cell line with IC50 of 9.33M.

引用

页码：800 / 806

页数：7

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