Bioactive Tyrosine-Derived Cytochalasins from Fungus Eutypella sp D-1

被引：32
|
作者：
Liu, Jing-Tang [1 ]
Hu, Bo [1 ]
Gao, Yun [1 ]
Zhang, Jian-Peng [1 ]
Jiao, Bing-Hua [1 ]
Lu, Xiao-Ling [1 ]
Liu, Xiao-Yu [1 ]
机构：
[1] Second Mil Med Univ, Dept Biochem & Mol Biol, Coll Basic Med Sci, Shanghai, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2014年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Eutypella; Cytochalasins; Arctic fungi; Fungi; Cytotoxic activity; ACTIN; METABOLITES;
D O I：
10.1002/cbdv.201300218
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three new cytochalasins Z(24), Z(25), Z(26) (1-3, resp.) and one known compound, scoparasin B (4), were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of the Arctic. The structures of 1-3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF-7 cell line with IC50 of 9.33M.
引用
收藏
页码：800 / 806
页数：7
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