α-Fluoroallenoate Synthesis via N-Heterocyclic Carbene-Catalyzed Fluorination Reaction of Alkynals

被引：29

作者：

Wang, Xu ^{[1
]}

Wu, Zijun ^{[1
]}

Wang, Jian ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 117543, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 03期

关键词：

ENANTIOSELECTIVE FLUORINATION; ASYMMETRIC FLUORINATION; EFFICIENT SYNTHESIS; BETA-KETOESTERS; UMPOLUNG; ALLENES; TRIFLUOROMETHYLATION; ORGANOCATALYSIS; GENERATION; ALDEHYDES;

D O I：

10.1021/acs.orglett.5b03615

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first catalytic alpha-fluoroallenoate synthesis is described. With a suitable combination of N-heterocyclic carbene precatalyst, base, and fluorine reagent, the reaction proceeded smoothly to yield a wide range of alpha-fluoroallenoates with excellent chemoselectivity. These substituted alpha-fluorinated allenoates have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful fluorine-containing building blocks.

引用

页码：576 / 579

页数：4

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