N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN

被引：26
|
作者：
Fan, Ye-Cheng [1 ]
Du, Guang-Fen [1 ]
Sun, Wan-Fu [2 ]
Kang, Wei [1 ]
He, Lin [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Xinjiang 832003, Peoples R China
[2] Xinjiang Univ, Ctr Phys & Chem Anal, Urumqi 830046, Xinjiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 17期
关键词：
N-Heterocyclic carbene; Cyanomethylation; Carbonyl compounds; Trimethylsilylacetonitrile; beta-Hydroxynitriles; GROUP-TRANSFER POLYMERIZATION; CARBONYL-COMPOUNDS; COOPERATIVE CATALYSIS; ACETONITRILE; ACTIVATION; CYANOSILYLATION; KETONES; BASE; COMPLEX; IMINES;
D O I：
10.1016/j.tetlet.2012.02.080
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Heterocyclic carbenes (NHCs) have been served as efficient catalysts for cyanomethylation of carbonyl compounds. In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give beta-hydroxynitriles in moderate to high yields. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2231 / 2233
页数：3
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