Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate

被引：23
|
作者：
Mathiyalagan, Ramya [1 ,2 ]
Subramaniyam, Sathiyamoorthy [3 ]
Kim, Yeon Ju [3 ]
Natarajan, Sathishkumar [1 ,2 ]
Min, Jin Woo [3 ]
Kim, Se Young [3 ]
Yang, Deok Chun [1 ,2 ,3 ]
机构：
[1] Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin, South Korea
[2] Kyung Hee Univ, Coll Life Sci, Ginseng Bank, Yongin, South Korea
[3] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Mat & Proc, Yongin, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 03期
关键词：
Panax ginseng; compound k; polyethylene glycol; solubility; cancer; INTRACELLULAR DELIVERY; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; COMPOUND K; MICELLES;
D O I：
10.1080/09168451.2014.885827
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
引用
收藏
页码：466 / 468
页数：3
相关论文
共 50 条
  • [41] Frontal polymerization synthesis and characterization of temperature- and pH-sensitive hydrogels
    Qiao Feng
    Qingzhi Yan
    Changchun Ge
    [J]. Colloid and Polymer Science, 2013, 291 : 1163 - 1170
  • [42] Synthesis and characterization of pH-sensitive drinkable nanoparticles for oral delivery of ibuprofen
    Agostini, Azzurra
    Palmiero, Umberto Capasso
    Barbieri, Sara D. A.
    Lupi, Monica
    Moscatelli, Davide
    [J]. NANOTECHNOLOGY, 2018, 29 (22)
  • [43] Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers
    XIA JiaLiangCHEN JieTIAN HuaYu CHEN XueSi Key Laboratory of Polymer Ecomaterials
    Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun ChinaGraduate University of Chinese Academy of SciencesBeijing China
    [J]. Science China(Chemistry), 2010, 53 (03) : 502 - 507
  • [44] Synthesis and Characterization of a Novel Starch-based pH-sensitive Hydrogel
    Du, Jie
    Zhao, Tianqin
    Liu, Yi
    Jie, Jing
    [J]. SENSORS, MEASUREMENT AND INTELLIGENT MATERIALS, PTS 1-4, 2013, 303-306 : 2602 - +
  • [45] Synthesis and Characterization of pH-Sensitive and Thermosensitive Double Hydrophilic Graft Copolymers
    Tu, You-Liang
    Wang, Cheng-Chien
    Chen, Chuh-Yung
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2011, 49 (13) : 2866 - 2877
  • [46] Frontal polymerization synthesis and characterization of temperature- and pH-sensitive hydrogels
    Feng, Qiao
    Yan, Qingzhi
    Ge, Changchun
    [J]. COLLOID AND POLYMER SCIENCE, 2013, 291 (05) : 1163 - 1170
  • [47] Synthesis and characterization of N-acylated, pH-sensitive 'caged' aminophospholipids
    Drummond, D. C.
    Daleke, D. L.
    [J]. Chemistry and Physics of Lipids, 75 (02):
  • [48] Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
    Kim, B
    Peppas, NA
    [J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2002, 13 (11) : 1271 - 1281
  • [49] SYNTHESIS AND CHARACTERIZATION OF N-ACYLATED, PH-SENSITIVE CAGED AMINOPHOSPHOLIPIDS
    DRUMMOND, DC
    DALEKE, DL
    [J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1995, 75 (01) : 27 - 41
  • [50] Synthesis and characterization of a pH-sensitive shielding system for polycation gene carriers
    Xia JiaLiang
    Chen Jie
    Tian HuaYu
    Chen XueSi
    [J]. SCIENCE CHINA-CHEMISTRY, 2010, 53 (03) : 502 - 507
12345