Synthesis and pharmacokinetic characterization of a pH-sensitive polyethylene glycol ginsenoside CK (PEG-CK) conjugate

被引：23
|
作者：
Mathiyalagan, Ramya [1 ,2 ]
Subramaniyam, Sathiyamoorthy [3 ]
Kim, Yeon Ju [3 ]
Natarajan, Sathishkumar [1 ,2 ]
Min, Jin Woo [3 ]
Kim, Se Young [3 ]
Yang, Deok Chun [1 ,2 ,3 ]
机构：
[1] Kyung Hee Univ, Coll Life Sci, Grad Sch Biotechnol, Yongin, South Korea
[2] Kyung Hee Univ, Coll Life Sci, Ginseng Bank, Yongin, South Korea
[3] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Mat & Proc, Yongin, South Korea
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 03期
关键词：
Panax ginseng; compound k; polyethylene glycol; solubility; cancer; INTRACELLULAR DELIVERY; POLY(ETHYLENE GLYCOL); BLOCK-COPOLYMERS; COMPOUND K; MICELLES;
D O I：
10.1080/09168451.2014.885827
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ginsenosides in Panax ginseng have vast structural and pharmacological efficacies. We covalently conjugated polyethylene glycol on the surface of CK (PEG-CK) through an acid-labile ester-linkage that showed increased solubility of CK. HPLC analysis showed that the release of CK was enhanced at acidic pH 5, whereas it was dramatically decreased at physiological pH 7.4. This might enhance the efficacy of CK.
引用
收藏
页码：466 / 468
页数：3
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