Catalyst-free Synthesis of 5-Arylimidazo[1,2-c]quinazoline Derivatives in Ionic Liquids

被引：4

作者：

Qiang, Wen-Wen ^{[1
]}

Zhang, Mei-Mei ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 01期

关键词：

ANNELATED QUINAZOLINE DERIVATIVES; VALENT TITANIUM REAGENT; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; IODINE; AGENTS; AID; INHIBITORS;

D O I：

10.1002/jhet.2613

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-(4,5-diphenyl-1H-imidazol-2-yl) aniline and aromatic aldehyde was treated in ionic liquids under catalyst-free condition and gave dehydrogenated 5-aryl-2,3-diphenylimidazo[1,2-c] quinazolines. The same reaction gave un-aromatized 5-aryl-2,3-diphenyl-5,6-dihydroimidazo[1,2-c] quinazoline derivatives while it was controlled in an inert gas. This procedure approach to imidazo[1,2-c] quinazolines has the advantages of milder reaction conditions, one-pot, catalyst free, high yields, and environmentally benign.

引用

页码：509 / 516

页数：8

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