Catalyst-free Synthesis of 5-Arylimidazo[1,2-c]quinazoline Derivatives in Ionic Liquids

被引：4
|
作者：
Qiang, Wen-Wen [1 ]
Zhang, Mei-Mei [1 ]
Wang, Xiang-Shan [1 ]
机构：
[1] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 01期
关键词：
ANNELATED QUINAZOLINE DERIVATIVES; VALENT TITANIUM REAGENT; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; IODINE; AGENTS; AID; INHIBITORS;
D O I：
10.1002/jhet.2613
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-(4,5-diphenyl-1H-imidazol-2-yl) aniline and aromatic aldehyde was treated in ionic liquids under catalyst-free condition and gave dehydrogenated 5-aryl-2,3-diphenylimidazo[1,2-c] quinazolines. The same reaction gave un-aromatized 5-aryl-2,3-diphenyl-5,6-dihydroimidazo[1,2-c] quinazoline derivatives while it was controlled in an inert gas. This procedure approach to imidazo[1,2-c] quinazolines has the advantages of milder reaction conditions, one-pot, catalyst free, high yields, and environmentally benign.
引用
收藏
页码：509 / 516
页数：8
相关论文
共 50 条
  • [11] Synthesis of tetra- and pentaaza heterocyclic systems and benzimidazo[1,2-c]quinazoline derivatives
    A. A. Harutyunyan
    Russian Journal of Organic Chemistry, 2014, 50 : 94 - 99
  • [12] Synthesis of benzoimidazo [1,2-c] quinazoline derivatives promoted by low-valent titanium
    Shi Da-Qing
    Li Zheng-Yi
    Dou Guo-Lan
    Shi Chun-Ling
    Wang Xiang-Shan
    Ji Shun-Jun
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2007, 28 (10): : 1889 - 1892
  • [13] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF AMINOACETYL AND AMINOETHYL DERIVATIVES OF INDOLE[1,2-C]QUINAZOLINE
    GRINEV, AN
    KURILO, GN
    CHERKASOVA, AA
    MASHKOVSKII, MD
    ANDREEVA, NI
    SOKOLOV, IK
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1978, 12 (02): : 97 - 101
  • [14] Design and Synthesis of Imidazo/Benzimidazo[1,2-c]quinazoline Derivatives and Evaluation of Their Antimicrobial Activity
    Nandwana, Nitesh Kumar
    Singh, Rajnish Prakash
    Patel, Om P. S.
    Dhiman, Shiv
    Saini, Hitesh Kumar
    Jha, Prabhat N.
    Kumar, Anil
    ACS OMEGA, 2018, 3 (11): : 16338 - 16346
  • [15] Synthesis of tetra- and pentaaza heterocyclic systems and benzimidazo[1,2-c]quinazoline derivatives
    Harutyunyan, A. A.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 50 (01) : 94 - 99
  • [16] Synthesis of benzimidazo[1,2-c]quinazoline-6(5H)-thiones
    Ivachtchenko, A
    Kovalenko, S
    Drushlyak, O
    HETEROCYCLIC COMMUNICATIONS, 2002, 8 (03) : 233 - 236
  • [17] New thienoyl-substituted pyrrolo[1,2-c] quinazoline derivatives
    Georgescu, Emilian
    Georgescu, Florentina
    Roibu, Constantin
    Iuhas, Paula C.
    Draghici, Constantin
    Filip, Petru I.
    ARKIVOC, 2008, : 60 - 67
  • [18] SYNTHESIS OF 2,3,5,6-TETRAHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES AS POTENTIAL NARCOTIC-ANTAGONISTS
    ANTONINI, I
    CRISTALLI, G
    FRANCHETTI, P
    GRIFANTINI, M
    MARTELLI, S
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1980, 17 (01) : 155 - 157
  • [19] Copper-Catalyzed Cascade Synthesis of 1H-Indolo[1,2-c]quinazoline Derivatives
    Zhang, Hao
    Jin, Yibao
    Liu, Hongxia
    Jiang, Yuyang
    Fu, Hua
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (34) : 6798 - 6803
  • [20] SYNTHESIS OF PERHYDROPYRAZINO[1,2-C]PYRIMIDINE DERIVATIVES
    MACHON, Z
    JASZTOLDHOWORKO, R
    FARMACO-EDIZIONE SCIENTIFICA, 1985, 40 (09): : 695 - 700
12345