The PafBC-mediated response sensitizes a bistable DNA damage response in Mycobacteria

被引：1
|
作者：
FitzGerald, Cody E. [1 ]
Keener, James P. [1 ]
机构：
[1] Univ Utah, Dept Math, 155 South 1400 East, Salt Lake City, UT 84112 USA
来源：
JOURNAL OF THEORETICAL BIOLOGY | 2021年 / 508卷
基金：
美国国家科学基金会;
关键词：
Switch-like; SOS response; LexA/RecA dependent response; PafBC-mediated response; Bifurcation; Hystersis; DNA damage response model; UV-INDUCED MUTAGENESIS; SOS-RESPONSE; REPAIR;
D O I：
10.1016/j.jtbi.2020.110462
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Due to the genotoxically challenging environments in which they live in, Mycobacteria have a complex DNA damage repair system that is governed by two major DNA damage responses, namely, the LexA/ RecA-dependent response and the newly characterized PafBC-mediated response (Muller et al., 2018). The LexA/RecA-dependent response is a well-known bistable response found in different types of bacteria, and the Mycobacteria-specific PafBC-mediated response interacts with and modifies the LexA/RecA dependent response (Muller et al., 2018). The interaction between the LexA/RecA-dependent response and the PafBC-mediated response has not been characterized mathematically. Our analysis shows that the addition of the PafBC-mediated response sensitizes the overall DNA damage response, effectively lowering the DNA damage rate threshold for activation. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：7
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