Mild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents

被引：70

作者：

Cheung, Chi Wai ^{[1
]}

Ren, Peng ^{[1
]}

Hu, Xile ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Inorgan Synth & Catalysis, ISIC LSCI, CH-1015 Lausanne, Switzerland

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 09期

基金：

欧洲研究理事会;

关键词：

SONOGASHIRA REACTIONS; BROMIDES; IODIDES; ELECTROPHILES; NUCLEOPHILES; REACTIVITY; COMPLEX;

D O I：

10.1021/ol501087m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.

引用

页码：2566 / 2569

页数：4

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