Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

被引：42
|
作者：
Willand-Charnley, Rachel [1 ]
Puffer, Benjamin W. [1 ]
Dussault, Patrick H. [1 ]
机构：
[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 16期
基金：
美国国家科学基金会;
关键词：
ETHERS; OXIDATION; REAGENTS;
D O I：
10.1021/ja5026276
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.
引用
收藏
页码：5821 / 5823
页数：3
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