Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

被引：42

作者：

Willand-Charnley, Rachel ^{[1
]}

Puffer, Benjamin W. ^{[1
]}

Dussault, Patrick H. ^{[1
]}

机构：

[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 16期

基金：

美国国家科学基金会;

关键词：

ETHERS; OXIDATION; REAGENTS;

D O I：

10.1021/ja5026276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

引用

页码：5821 / 5823

页数：3

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