Association of the CYP2B6 c.516G>T Polymorphism with High Blood Propofol Concentrations in Women from Northern Greece

被引：27
|
作者：
Mastrogianni, Orthodoxia [1 ]
Gbandi, Emma [2 ]
Orphanidis, Amvrosios [1 ]
Raikos, Nikolaos [1 ]
Goutziomitrou, Evangelia [3 ]
Kolibianakis, Efstratios M. [3 ]
Tarlatzis, Basil C. [3 ]
Goulas, Antonis [2 ]
机构：
[1] Aristotle Univ Thessaloniki, Sch Med, Dept Forens Med & Toxicol, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Med, Dept Pharmacol, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, Sch Med, Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1,Unit Human Reprod, Thessaloniki 54124, Greece
来源：
DRUG METABOLISM AND PHARMACOKINETICS | 2014年 / 29卷 / 02期
关键词：
blood propofol; GC/MS; CYP2B6; gene polymorphism; HUMAN LIVER; UGT1A9; PHARMACOKINETICS; GLUCURONIDATION; METABOLITES; EXPRESSION; IMPACT; GENE;
D O I：
10.2133/dmpk.DMPK-13-NT-092
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate analysis using age, height, weight and smoking status as covariates, as well as the Mann-Whitney non-parametric test, revealed a strong trend of association of the T allele with high propofol concentrations determined in whole blood, shortly after a single bolus dose. Propofol concentrations which were higher than one standard deviation of the mean were almost invariably associated with carriage of the T allele.
引用
收藏
页码：215 / 218
页数：4
相关论文
共 50 条
  • [41] Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis
    Nightingale, Sam
    Tran Thi Hong Chau
    Fisher, Martin
    Nelson, Mark
    Winston, Alan
    Else, Laura
    Carr, Daniel F.
    Taylor, Steven
    Ustianowski, Andrew
    Back, David
    Pirmohamed, Munir
    Solomon, Tom
    Farrar, Jeremy
    Toerok, M. Estee
    Khoo, Saye
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (08) : 4511 - 4518
  • [42] CYP2B6 18492T→C Polymorphism Compromises Efavirenz Concentration in Coinfected HIV and Tuberculosis Patients Carrying CYP2B6 Haplotype*1/*1
    Manosuthi, Weerawat
    Sukasem, Chonlaphat
    Thongyen, Supeda
    Nilkamhang, Samruay
    Manosuthi, Sukanya
    Sungkanuparph, Somnuek
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (04) : 2268 - 2273
  • [43] The implications of a high allelic frequency of CYP2B6 G516T in ethnic Chinese persons -: Reply to Tong et al.
    Ribaudo, Heather J.
    Haas, David W.
    Acosta, Edward P.
    CLINICAL INFECTIOUS DISEASES, 2006, 43 (04) : 542 - 544
  • [44] Influence of CYP2B6 516G>T polymorphism and interoccasion variability (IOV) on the population pharmacokinetics of efavirenz in HIV-infected South African children
    M. Viljoen
    M. O. Karlsson
    T. M. Meyers
    H. Gous
    C. Dandara
    M. Rheeders
    European Journal of Clinical Pharmacology, 2012, 68 : 339 - 347
  • [45] CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-Treated HIV-Infected Patients in Botswana
    Vujkovic, Marijana
    Bellamy, Scarlett L.
    Zuppa, Athena F.
    Gastonguay, Marc
    Moorthy, Ganesh S.
    Ratshaa, Bakgaki R.
    Han, Xiaoyan
    Steenhoff, Andrew P.
    Mosepele, Mosepele
    Strom, Brian L.
    Aplenc, Richard
    Bisson, Gregory P.
    Gross, Robert
    JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2017, 75 (04) : 488 - 491
  • [46] Association of CYP2B6 (G15631T) polymorphism with Clopidogrel resistance and genetic predisposition to Acute Coronary Syndromes (ACSs) in Morocco
    Hassani Idrissi, Hind
    El Khorb, Nada
    Akoudad, Abdelhafid
    Habbal, Rachida
    Nadifi, Sellama
    GENE REPORTS, 2018, 11 : 244 - 249
  • [47] Association between ABCB1 3435C>T and CYP2B6 516G>T and high-density lipoprotein cholesterol (HDL-c) changes in anti retroviral-naive patients receiving first-line efavirenz (EFV)-based regimens
    Mahungu, T. W.
    Nair, D.
    Smith, C. J.
    Youle, M.
    Johnson, M. A.
    Khoo, S. H.
    Back, D. J.
    Owen, A.
    HIV MEDICINE, 2009, 10 : 49 - 50
  • [48] Evaluation of CYP2B6 G15631T Polymorphism as a Risk Factor for Development of Chronic Myeloid Leukemia
    Essa, Enas
    Alhassanin, Suzan
    Radwan, Wafaa
    Hagag, Mayada
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 : S286 - S286
  • [49] CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea:: implications for HIV/AIDS treatment
    Mehlotra, Rajeev K.
    Bockarie, Moses J.
    Zimmerman, Peter A.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2007, 64 (03) : 391 - 395
  • [50] A Single-Nucleotide Polymorphism in CYP2B6 Leads to >3-Fold Increases in Efavirenz Concentrations in Plasma and Hair Among HIV-Infected Women
    Gandhi, Monica
    Greenblatt, Ruth M.
    Bacchetti, Peter
    Jin, Chengshi
    Huang, Yong
    Anastos, Kathryn
    Cohen, Mardge
    DeHovitz, Jack A.
    Sharp, Gerald B.
    Gange, Stephen J.
    Liu, Chenglong
    Hanson, Susan C.
    Aouizerat, Bradley
    JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (09): : 1453 - 1461
12345