Association of the CYP2B6 c.516G>T Polymorphism with High Blood Propofol Concentrations in Women from Northern Greece

被引：27
|
作者：
Mastrogianni, Orthodoxia [1 ]
Gbandi, Emma [2 ]
Orphanidis, Amvrosios [1 ]
Raikos, Nikolaos [1 ]
Goutziomitrou, Evangelia [3 ]
Kolibianakis, Efstratios M. [3 ]
Tarlatzis, Basil C. [3 ]
Goulas, Antonis [2 ]
机构：
[1] Aristotle Univ Thessaloniki, Sch Med, Dept Forens Med & Toxicol, Thessaloniki 54124, Greece
[2] Aristotle Univ Thessaloniki, Sch Med, Dept Pharmacol, Thessaloniki 54124, Greece
[3] Aristotle Univ Thessaloniki, Sch Med, Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1,Unit Human Reprod, Thessaloniki 54124, Greece
来源：
DRUG METABOLISM AND PHARMACOKINETICS | 2014年 / 29卷 / 02期
关键词：
blood propofol; GC/MS; CYP2B6; gene polymorphism; HUMAN LIVER; UGT1A9; PHARMACOKINETICS; GLUCURONIDATION; METABOLITES; EXPRESSION; IMPACT; GENE;
D O I：
10.2133/dmpk.DMPK-13-NT-092
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate analysis using age, height, weight and smoking status as covariates, as well as the Mann-Whitney non-parametric test, revealed a strong trend of association of the T allele with high propofol concentrations determined in whole blood, shortly after a single bolus dose. Propofol concentrations which were higher than one standard deviation of the mean were almost invariably associated with carriage of the T allele.
引用
收藏
页码：215 / 218
页数：4
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